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Exhaustion
Exhaustion


















The University of North Carolina at Chapel Hill
Lineberger Comprehensive Cancer Center
PI: Jessica Thaxton, PhD, MsCR
Translational Tumor Immunotherapy Research
Mission:
Our lab seeks to make basic mechanistic discoveries at the bench, translating these discoveries to clinical trials for patients with cancer. We study abnormal cell stress signaling, metabolic processes, and organelle dynamics that occur in immune cells in human and murine cancers shaped by the tumor microenvironment. We work to repair these dysregulated processes to create novel therapies for cancer patients. Our collaborations include partnerships with basic science teams and head and neck cancer, melanoma, sarcoma, and metastatic bone disease medical and surgical oncologists. We are passionate about novel exploration of immune cells in tumors driven by the diverse interests of our vibrant laboratory team.

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